Eglonil: instructions for use, dosage and contraindications

Clinico-pharmacological group

Antipsychotic drug (neuroleptic).

Release form and composition

The drug is available in the form of:

  • Capsules;
  • Pills;
  • Solution for intramuscular injection.

The main active ingredient in all forms of release is sulpiride. Dosages can be different and are selected by a doctor.

Indications for use

As a monotherapy or in combination with other psychotropic drugs:

  • Acute schizophrenia;
  • Acute delirious states;
  • Depression of various etiologies;
  • Neurosis and panic attacks in the elderly, when other methods of treatment are ineffective (only for capsules);
  • Behavioral disorders (agitation, self-harm, stereotype) in children over 6 years of age, especially in combination with autism syndromes (for capsules only).


  • Prolactin-dependent tumors;
  • Hyperprolactinemia;
  • Acute toxicity with ethanol, hypnotic drugs, opioid analgesics;
  • Affective disorders, manic psychosis;
  • Pheochromocytoma;
  • Lactation period;
  • Age up to 18 years (tablets and solution);
  • Age up to 6 years (capsules);
  • Concurrent use with sultopride, dopaminergic receptor agonists;
  • The presence of an allergic reaction to sulpiride or drug excipients.

Due to the presence of lactose in Eglon, it is contraindicated for congenital galactosemia, glucose or malabsorption malabsorption syndrome and lactase deficiency.

Precautionary measures:

  • The prescription of the drug for pregnant women is not recommended, unless the doctor, assessing the suitability of the benefits and risks for the mother and the fetus, concludes that the use of this medication is necessary;
  • It is not recommended to use "Eglon" together with ethanol, levodopa and some other drugs;
  • “Eglonil” is prescribed with caution in patients with renal and / or hepatic insufficiency, a history of malignant neuroleptic syndrome, epilepsy or history of seizures,severe heart disease, arterial hypertension, patients with parkinsonism, dysmenorrhea, in old age.

Methods of use and dosage

Solution for intramuscular injection.

  • In acute and chronic psychosis, therapy begins with intramuscular injections at a dose of 400-800 mg / day. Treatment can last up to 2 months. The task of therapy - the lowest possible effective dosage of the drug. When i / m administration of sulpiride, it is necessary to follow the usual rules for injection: enter the drug in the upper quadrant of the gluteus muscle, treating the skin with antiseptic. Depending on the picture of the disease, intramuscular injections of sulpiride are prescribed 1-3 times a day, which allows to mitigate or suspend the symptoms of the disease. As soon as the drug begins to act, it is necessary to transfer the patient to Eglonil tablets or capsules.
  • Tablets and capsules are taken 1-3 times a day orally with a small amount of water. Drug intake does not depend on food intake.
  • The main thing in therapy is to achieve the minimum effective dosage of the drug.


  • Schizophrenia, acute delirious psychosis, depression: the daily dose should be from 200 to 1000 mg, divided into several applications per day;
  • Neurosis and increased anxiety in elderly patients: the daily dose should be from 50 to 150 mg in the direction of 4 months very much;
  • Behavioral disorders in children: the daily dose should be from 5 to 10 mg per 1 kg of body weight;
  • Doses for the elderly: the initial dose of sulpiride is 1 / 4-1 / 2 doses of adult patients;
  • Doses in patients with impaired renal function;
  • Due to the fact that sulpiride is eliminated from the body mainly through the kidneys, it is required to reduce the amount of Eglonil, depending on the CC.

It is not recommended to use the drug in any form in the second half of the day. This is due to the influence of the drug on the level of brain activity.

Side effects

The frequency of manifestations is less than that of Eglonil analogues.

  • On the part of the endocrine system: reversible hyperprolactinemia, galactorrhea, amenorrhea, gynecomastia, impotence and frigidity are likely to occur;
  • During therapy with this drug, there may be an increase in sweating and an increase in the weight of the patient.
  • On the part of the digestive system: increased activity of liver enzymes;
  • On the part of the central nervous system: sedation, drowsiness, dizziness, tremor, premature dyskinesia, extrapyramidal syndrome and related disorders;
  • With the development of hyperthermia, it is necessary to cancel the medication, since an increase in body temperature may indicate the occurrence of a malignant antipsychotic syndrome;
  • On the part of the cardiovascular system: tachycardia, it is likely that there will be an increase or decrease in blood pressure, in exceptional cases, orthostatic hypotension may occur, the QT interval will lengthen, and the torsade depointes syndrome will rarely occur;
  • Allergic reactions: skin rash is likely.


Information is limited. There are no peculiar symptoms, but there may be: dyskinesia with spastic torticollis, nebula of vision, arterial hypertension, sedation, nausea, extrapyramidal symptoms, dry mouth, nausea, increased sweating and gynecomastia, the onset of MNS is likely. In some patients: part of the drug is excreted by hemodialysis. In the absence of a peculiar antidote, symptomatic and supportive therapy should be used, with precise control of the respiratory function and control of cardiac work (risk of prolonged QT interval), which should last until the patient heals, central anticholinergic blockers are prescribed during the development of embodied extrapyramidal syndrome.

special instructions

Malignant neuroleptic syndrome: when hyperthermia develops, the undiagnosed origin of sulpiride should be canceled, as this may be one of the symptoms of the malignant syndrome described when using neuroleptics (pallor, hyperthermia, autonomic dysfunction, impaired consciousness, muscle rigidity).
Symptoms of autonomic dysfunction: increased sweating and labile blood pressure, are able to precede the onset of hyperthermia and, therefore, constitute the initial warning signs.
With the exception of cases of emergency intervention, patients who require neuroleptic treatment will be recommended to perform an ECG in the status assessment process.

The control during treatment with sulpiride should be strengthened:

  • In patients with epilepsy;
  • With therapy in the elderly.

The use of alcohol or the use of pharmaceutical products containing ethyl alcohol during drug therapy is strictly prohibited.

Impact on the ability to drive vehicles and control mechanisms.

During therapy, "Eglonil" is required to limit the management of transport, work with the mechanisms and the use of alcohol-containing beverages.

Pregnancy and lactation

Experiments on animals did not reveal teratogenic effects. Some women who took low doses of sulpiride during pregnancy (approximately 200 mg per day) had no teratogenic effect. With regard to the use of large doses of "Eglon" data are not available. There are no data on the effect of neuroleptic substances taken during pregnancy, the formation of the brain of the fetus. So, as a precautionary measure, it is advisable not to use Eglonil during pregnancy.
However, in the case of using this medication during pregnancy, it is recommended to limit the dose and duration of the course of therapy. In newborns whose mothers received long-term therapy with the highest doses of neuroleptics, gastrointestinal problems were rarely observed (abdominal distension, etc. The drug penetrates into breast milk, therefore it is necessary to stop taking the drug during lactation.

Pharmacy and expiration dates

"Eglonil" prescription. It is stored at a temperature below 30 ° С in a space that is difficult for children. Shelf life - 3 years. Do not use after the expiration date indicated on the package.

Date: 16.10.2018, 15:40 / Views: 71261

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